Page 16 - Abacoa Community News - September '22

Page 16, Abacoa

Research Scientists Discover Antibodies from page 12 NeiGhbOrhOOd News

the virus,” says co-senior author Ian Wilson, DPhil, Hansen Abacoa Community Garden
Professor of Structural Biology and Chair of the Department
of Integrative Structural and Computational Biology.
It’s important to note that the macaque’s gene Summertime Okra The Recipe
coding for these broad neutralizing antibodies – 4 cups of ½-inch slices of
known as IGHV3-73 – is not the same in humans. The A benefit of okra okra (tops removed)
dominant immune response in humans is related to the for local gardeners is 2 large tomatoes chopped
IGHV3-53 gene, which produces a potent but much that it grows well in into ½-inch cubes
narrower neutralizing antibody response. However, the the heat of summer. 1 tablespoon olive oil
scientists say this discovery opens the door to rationally Okra can withstand 1 teaspoon kosher salt
design and engineer vaccines or vaccine-adjuvant the sweltering days Fresh ground pepper to taste
combinations that elicit more broad protection against while we wait until Directions
SARS-CoV-2 and its many variants. we ha ve c ool e r Line a baking sheet or
“According to our study, the macaques have weather to set out glass baking dish with foil
an antibody gene that offers them more protection seeds and new plants. and brush with olive oil.
against SARS viruses. This observation teaches us For the uninitiated, Add vegetables and drizzle
that studying the effect of a vaccine in monkeys can that generally would a tablespoon of oil, and salt
only take us so far but also reveals a new target for be northerners, okra and pepper, stir gently to spread. Bake for 20 minutes at
our vaccine efforts that we might be able to exploit can taste slimy when 450 degrees Fahrenheit until tender with charred tips.
by advanced protein design strategies,” adds Dennis cooked improperly, Yum. Yum. Maybe we should nominate okra to be our
Burton, Ph.D., co-senior author and chair of the or be yummy but not national vegetable. Move aside, pumpkin.
Department of Immunology and Microbiology. very healthy, when it Garden membership runs from Aug. 1 to July 31.
Because the genetics do differ, Andrabi urges that is fried. A search for Download forms at www.abacoa.com/abacoa-community-
more investigation is needed – not only for identifying an alternative that’s still tasty, leads to roasting okra mixed garden or find one in the mailbox at the garden entrance
new strategies against SARS viruses, but also for with tomatoes. The latter evidently counteracts the otherwise at 1022 Community Drive. There is a waiting list for
making sure scientists are using the best translational mushy content. The result is a delicious dish that is low in independent beds but if interested, just check the box.
models for their research. calories but high in fiber, packed with nutrients like folate Stop by, especially Saturday mornings, and check out our
In addition to Andrabi, Wilson and Burton, authors and vitamins A, C and K, beta carotene and lutein. Facebook page.
of the study, “Broadly neutralizing antibodies to
SARS-related viruses can be readily induced in rhesus
macaques,” include Wan-ting He, Meng Yuan, Sean
Callaghan, Rami Musharrafieh, Ge Song, Nathan Beutler,
Wen-Hsin Lee, Peter Yong, Jonathan L. Torres, Panpan
Zhou, Fangzhu Zhao, Xueyong Zhu, Linghang Peng, Deli
Huang, Fabio Anzanello, James Ricketts, Mara Parren,
Elijah Garcia, David Nemazee, Bryan Briney and Andrew You’re Retired
B. Ward of Scripps Research; Murillo Silva and Mariane
Melo of Massachusetts Institute of Technology (MIT); Your Money Isn’t.
Melissa Ferguson and William Rinaldi of Alpha Genesis;
Stephen A. Rawlings, Davey M. Smith and Yana Safonova
of University of California, San Diego (UCSD); Thomas To learn why consolidating your
F. Rogers of Scripps Research and UCSD; Jennifer M. retirement accounts to Edward Jones
Dan and Alessandro Sette of UCSD and La Jolla Institute makes sense, contact your Edward
for Immunology; Zeli Zhang and Daniela Weiskopf of La
Jolla Institute for Immunology; Shane Crotty of UCSD Jones nancial advisor today.
and the La Jolla Institute for Immunology; and Darrell J.
Irvine of MIT and Howard Hughes Medical Institute.
This work and the researchers involved were
supported by funding by NIH CHAVD UM1 AI44462 Sally S Stahl, AAMS® www.edwardjones.com
b
P I S r e
C
m
M

e
(to D.R.B., A.B.W., and I.A.W.), the IAVI Neutralizing Financial Advisor
Antibody Center, the Bill and Melinda Gates Foundation 1851 W Indiantown Rd Ste 106
OPP1170236 and INV-004923 (to I.A.W., A.B.W., and Jupiter, FL 33458
D.R.B.), the Translational Virology Core of the San 561-748-7600
Diego Center for AIDS Research (CFAR) grant NIH
AI036214 (to D.M.S.), NIH 5T32AI007384 (to S.A.R.),
and the John and Mary Tu Foundation and the James B.
Pendleton Charitable Trust (to D.R.B.). D.H. and D.N.
were supported in part by R01AI073148.

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