Page 11 - Abacoa Community News - March '23
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      Max Planck Florida Institute from page 10          against ER stress, resulting from the accumulation of the      “Regular physical
                                                         unfolded/misfolded proteins.                      activity is suggested
      Up Next For Science Meets Music Events                One group of proteins associated with the aging   to be an effective
         March 15, Science Meets Music: PFI Research Group   process is the mitochondrial heat shock protein 60   intervention in
      Leader Hidehiko Inagaki will discuss his research into   (HSP60), which has been demonstrated to play a   improving age -
      how cellular and network mechanisms influence brain   protective role in the ability for cells to remain active and   related diseases such
      functions like movement and decision-making. He will be   healthy. Currently, there is limited research investigating   as osteoporosis,
      joined by musicians Jordan Anderson (cello) and Royhei   the effects of resistance training in older adults on the   sarcopenia or
      Yasuda (cello), both of whom are also MPFI researchers.   expression of HSP60 and Klotho, a gene involved in the   muscle  loss  and
      Admission is free, and registration is required.   aging process in mammals.                         dynapenia or loss
         April 5, Science Meets Music: Daniela Sammler of      A new study by researchers at Florida Atlantic   of muscle strength,
      the Max Planck Institute for Empirical Aesthetics will   University, in collaboration with the University of León   c a rdi ova sc ul a r
      discuss her research on music and learning, along with   in Spain, examined whether an eight-week resistance   diseases, and type 2 diabetes,” said Chun-Jung “Phil”
      pianist Patricia Izbicki, also a neuroscientist by training.  training program would modulate the oxidative status, the   Huang, Ph.D., co-author and a professor in the Department
         Science Meets Music takes place at the Benjamin   UPR activation and key inflammatory pathways as well   of Exercise Science and Health Promotion within FAU’s
      Upper School, 4875 Grandiflora Circle, Palm Beach   as their relationships with HSP60 and Klotho proteins.  Charles E. Schmidt College of Science. “Although the
      Gardens, FL 33418. Doors open at 6 p.m. The program      For the study, researchers analyzed these proteins in   beneficial effects of regular physical exercise to alleviate
      begins at 6:15.                                    peripheral blood mononuclear cells of elderly subjects.   inflammation and oxidative stress are well-established, the
         There is no charge to attend, but advance registration   In addition, they utilized computer simulation to predict   processes of these physiological adaptations with regard
      is  required  and  can  be  made  at  the key proteins associated with these biomolecules   to protein folding or UPR remains to be explored. That is
      smm-registration/.                                 underlying physiological adaptations to exercise.   why we used a systems biology approach for our study.”
                                                                                                             The resistance training protocol for the study consisted
      Florida Atlantic University                        They collected blood samples approximately five to     of 16 sessions over eight weeks (two sessions per week),
                                                         six days  before  and  after the training  period  and just
                                                         before training intervention in young subjects who were   with a minimum of 48 hours between sessions.  The
       Effects Of Resistance Training In Older           included for basal assessments. Researchers also analyzed   participants started with a 10-minute warm-up on a
       Adults At The Cellular Level                      various oxidative stress biomarkers in peripheral blood   cycle ergometer. Subsequently, eight different resistance
       By Gisele Galoustian                              mononuclear cells.                                exercises (leg press, ankle extension, bench press, leg
          Aging involves                                    Results of the study, published in the journal   extension, bicep curl, pec deck, high pulley traction, and
       a balance between                                 Antioxidants, demonstrated that the levels of the   dumbbell lateral lift) were performed using the exercise
       oxidants and                                      inflammatory proteins (pIRAK1, TLR4, and TRAF6), as   device. For each exercise, participants performed three
       antioxidants,  low-                               well as different markers of the redox balance (catalase,   sets of 12-8-12 repetitions. There was a two-to-three-
       grade inflammation                                GSH, LP, NRF2, PC, ROS, SOD1, and SOD2) remained   minute rest between each repetition and a three-minute
       and a protein response that occurs at the cellular level,   unchanged with training. Importantly, untrained elderly   rest between each exercise.
       which is responsible for many health disorders.   subjects showed a significant reduction in pIRE1/IRE1      “We know how very important physical activity is
          Exercise has been shown to regulate the inflammatory   ratio when compared to trained elderly subjects. Such   for older adults and our study takes research one step
       response, balance oxidants such as free radicals that build   a finding was further confirmed by a gene ontology   further in helping to elucidate the benefits of exercise in
       up in the cells and damage DNA; and ameliorate the   analysis, showing that endoplasmic reticulum stress   this population,” said Huang.
       process by which cells protect themselves against these   is a key mechanism modulated by IRE1. Additionally,      Study co-authors are  senior author Brisamar
       stressors. Furthermore, resistance training in older adults   analysis did not show the training effect on the   Estébanez,  Ph.D., Marta Rivera-Viloria,  and  José A.
       is recommended to help maintain muscle, flexibility and   expression of HSP60 and Klotho or their relationships   de Paz, M.D., all with the University of León; José E.
       balance.                                          with other outcome variables. Although elderly male and   Vargas, Ph.D., Universidad Federal do Paraná, Curtiba;
          Aging and related diseases are associated with   female subjects were included in the training program,   and Nishant P. Visavadiay, Ph.D., and Andy V. Kahmoui,
       alterations in oxidative status and low-grade inflammation,   researchers did not find any sex effects in the study. These   Ph.D., both with FAU’s Department of Exercise Science
       as well as a decreased endoplasmic reticulum (ER)   findings might partially support the modulatory effect of   and Health Promotion.
       unfolded protein response (UPR). UPR is a functional   resistance training on the endoplasmic reticulum in the
       mechanism by which cells attempt to protect themselves   elderly.

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